ea0025p65 | Clinical biochemistry | SFEBES2011
Teo Luke
, Mok Michelle
, Macnair Andrew
, Nunkoo Prakashmini
, Lim Albert
, Muttiah Siobhan
, Warlow Margaret
, Dipper Christian
, Quinton Richard
Introduction: Proton pump inhibitors (PPIs) were until very recently perceived to be safe, effective and inexpensive. As a result they are widely prescribed empirically, beyond their core indications. However dose-dependent adverse reactions increasingly reported include diarrhoea, resistant hypomagnesaemia/hypocalcaemia and interstitial nephritis. Moreover, they are associated with increased rates of vertebral and wrist fractures, and increased C. difficile carriage rate....